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Oakes, Scott
One or more keywords matched the following properties of Oakes, Scott
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keywords Protein Misfolding
overview Scott Oakes’s laboratory studies how mammalian cells commit “suicide” in response to various forms of damage and what goes wrong with this process in cancer and other diseases. In particular, they focus on a type of stress that occurs when the cell’s protein folding factory—an organelle called the endoplasmic reticulum—is overwhelmed and protein quality control fails. He is actively engaged in developing drugs to control cell fate under these conditions, which have potential to benefit patients with diseases from cancer to neurodegeneration.
One or more keywords matched the following items that are connected to Oakes, Scott
Item TypeName
Concept DNA-Binding Proteins
Concept Microtubule-Associated Proteins
Concept Membrane Proteins
Concept Nerve Tissue Proteins
Concept Protein-Tyrosine Kinases
Concept Proto-Oncogene Proteins
Concept Proteins
Concept Protein Biosynthesis
Concept Milk Proteins
Concept Protein Structure, Tertiary
Concept RNA-Binding Proteins
Concept Apoptosis Regulatory Proteins
Concept Protein Folding
Concept rab GTP-Binding Proteins
Concept bcl-2-Associated X Protein
Concept Proto-Oncogene Proteins c-bcl-2
Concept Oncogene Protein v-akt
Concept Recombinant Proteins
Concept Ubiquitin-Protein Ligases
Concept Unfolded Protein Response
Concept BH3 Interacting Domain Death Agonist Protein
Concept Adaptor Proteins, Signal Transducing
Concept Oncogene Protein v-crk
Concept CDC2 Protein Kinase
Concept Calcium-Calmodulin-Dependent Protein Kinases
Concept Mutant Proteins
Concept Insulin Receptor Substrate Proteins
Concept Intracellular Signaling Peptides and Proteins
Concept Protein Unfolding
Concept Carrier Proteins
Concept Neoplasm Proteins
Concept Recombinant Fusion Proteins
Concept Tumor Suppressor Protein p53
Concept Vesicular Transport Proteins
Concept Adaptor Proteins, Vesicular Transport
Concept Protein Kinase Inhibitors
Concept bcl-2 Homologous Antagonist-Killer Protein
Concept GPI-Linked Proteins
Academic Article Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma.
Academic Article Divergent allosteric control of the IRE1a endoribonuclease using kinase inhibitors.
Academic Article Untangling the web: mitochondrial fission and apoptosis.
Academic Article IRE1a induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.
Academic Article Erratum: Proteostasis control by the unfolded protein response.
Academic Article IRE1a cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.
Academic Article BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis.
Academic Article Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. Potential role of JAK kinases.
Academic Article The control of endoplasmic reticulum-initiated apoptosis by the BCL-2 family of proteins.
Academic Article IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.
Academic Article Signaling via IL-2 and IL-4 in JAK3-deficient severe combined immunodeficiency lymphocytes: JAK3-dependent and independent pathways.
Academic Article Akt and autophagy cooperate to promote survival of drug-resistant glioma.
Academic Article Regulation of endoplasmic reticulum Ca2+ dynamics by proapoptotic BCL-2 family members.
Academic Article The role of endoplasmic reticulum stress in human pathology.
Academic Article Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum.
Academic Article Immune evasion mediated by tumor-derived lactate dehydrogenase induction of NKG2D ligands on myeloid cells in glioblastoma patients.
Academic Article Golgi fragmentation precedes neuromuscular denervation and is associated with endosome abnormalities in SOD1-ALS mouse motor neurons.
Academic Article A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis.
Academic Article CDK1 inhibition targets the p53-NOXA-MCL1 axis, selectively kills embryonic stem cells, and prevents teratoma formation.
Academic Article Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress.
Academic Article Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis.
Academic Article A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stress.
Academic Article Blocking the mitochondrial apoptotic pathway preserves motor neuron viability and function in a mouse model of amyotrophic lateral sclerosis.
Academic Article Signaling cell death from the endoplasmic reticulum stress response.
Academic Article Allosteric inhibition of the IRE1a RNase preserves cell viability and function during endoplasmic reticulum stress.
Academic Article CPEB4 links the clock and the UPR to protect the liver.
Academic Article Endoplasmic reticulum proteostasis: a key checkpoint in cancer.
Academic Article The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic reticulum stress.
Academic Article Proteostasis control by the unfolded protein response.
Academic Article Elastase 3B mutation links to familial pancreatitis with diabetes and pancreatic adenocarcinoma.
Grant BAX/BAK control ER-mitochondria apoptotic crosstalk
Grant Signaling Cell Death from the Endoplasmic Reticulum
Grant Role of the Unfolded Protein Response in Photoreceptor Degeneration
Grant Targeting the Unfolded Protein Response in PanNETs
Grant Attenuating ER and oxidative stress signaling to reduce cell degeneration in vivo
Academic Article Parallel Signaling through IRE1a and PERK Regulates Pancreatic Neuroendocrine Tumor Growth and Survival.
Academic Article Structural and functional basis for JAK3-deficient severe combined immunodeficiency.
Academic Article In vitro correction of JAK3-deficient severe combined immunodeficiency by retroviral-mediated gene transduction.
Academic Article Endoplasmic Reticulum Stress Signaling in Cancer Cells.
Academic Article Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses.
Academic Article The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity.
Academic Article Type I but Not Type II Calreticulin Mutations Activate the IRE1a/XBP1 Pathway of the Unfolded Protein Response to Drive Myeloproliferative Neoplasms.
Academic Article SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1a/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived Cells.
Concept Tripartite Motif Proteins
Concept X-Box Binding Protein 1
Concept Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Concept NLR Family, Pyrin Domain-Containing 3 Protein
Concept Myeloid Cell Leukemia Sequence 1 Protein
Concept Death-Associated Protein Kinases
Academic Article Deletion of the Unfolded Protein Response Transducer IRE1a Is Detrimental to Aging Photoreceptors and to ER Stress-Mediated Retinal Degeneration.
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  • Protein
  • Misfolding